The group of fluoroquinolones
with its most famous member ciprofloxacin is such a case: Fluoroquinolones
are some of the most frequently used broad-spectrum antibacterial antibiotics, and usually prescribed for respiratory, urinary or ear infections.
are a class of antibiotics highly valued for the treatment of bacterial infections.
In February 2018, a typhoid fever outbreak caused by Salmonella enterica serotype Typhi (Typhi), resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones
, and third-generation cephalosporins, was reported in Pakistan.
The US Food and Drug Administration is requiring labeling changes to clarify the risk of mental health side effects of fluoroquinolones
, a class of antibiotics that includes levofloxacin (Levaquin), ciprofloxacin (Cipro), ciprofloxacin extended-release tablets, moxifloxacin (Avelox), ofloxacin, gemifloxacin (Factive), delafloxacin (Baxdela), and more than 60 generic versions.
Food and Drug Administration (FDA) has ordered additional warnings to be placed on labels of fluoroquinolones
, a class of antibiotic medications commonly used to treat sinusitis, bronchitis, and urinary tract infections.
have caused at least 67 cases of life-threatening hypoglycemic coma, including 13 deaths and 9 permanent and disabling injuries, according to an internal safety review by the Food and Drug Administration.
Reports of cases submitted to the FDA and published medical literature of apparently healthy patients who experienced serious changes in mood, behavior, and blood glucose levels while being treated with systemic fluoroquinolones
We conducted a 6-month retrospective record review to determine whether there is bacterial culture data to support our initial empiric gram-negative double coverage with extended antipseudomonal beta-lactam (piperacillin-tazobactam) and fluoroquinolones
(ciprofloxacin and levofloxacin) in our military hospital patient population.
A review panel was formed by the FDA in November 2015 to evaluate the safety of fluoroquinolones
. The panel concluded that alternative agents should be administered, when possible, for the treatment of acute sinusitis, mild bronchitis and uncomplicated urinary tract infections because the risks outweigh the benefits in these situations.
are another important antibiotic class commonly used in adults to treat infections [8, 9].
are synthetic antimicrobial agents with a broad spectrum of activity and potent antibacterial activity against Gram-negative bacteria (1).