cyclooxygenase


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cy·clo·ox·y·gen·ase

 (sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Cox-1, cyclooxygenase-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox-2, cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
In total, 39 unique oxylipid metabolites derived from cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 epoxygenase (CYP), soluble epoxide hydrolase (sEH), and nonenzymatic (NE) pathways were quantified in the urinary bladder at the early (6 h) and late (48 h) stages after experimental inoculation of UPEC and ABEC (Table 1).
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Cyclooxygenase enzymes (COXs), comprising two isoforms (COX-1 and COX-2), are the key enzymes in prostaglandin generation [25].
Inflammation is interceded by prostaglandins produced by the cyclooxygenase pathway.
Flurbiprofen, a Cyclooxygenase Inhibitor, Protects Mice from Hepatic Ischemia/Reperfusion Injury by Inhibiting GSK-3b Signaling and Mitochondrial Permeability Transition.
James, Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2, The Journal of Immunology, 167(5), 2831-2838 (2001).
Hugely popular non-steroidal anti-inflammation drugs like aspirin, naproxen (marketed as Aleve) and ibuprofen (Advil, Motrin) all work by inhibiting or killing an enzyme called cyclooxygenase -- a key catalyst in production of hormone-like lipid compounds called prostaglandins that are linked to a variety of ailments, from headaches and arthritis to menstrual cramps and wound sepsis.
Anti-inflammatory and side effects of cyclooxygenase inhibitors.