cyclooxygenase-2


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Noun1.cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
Cox, cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder.
Further, the company confirmed that agaro-oligosaccharide can inhibit the generations of cyclooxygenase-2 (COX-2) and prostaglandin E synthase, two enzymes required in the synthesis of prostaglandin E2 (PGE2), which is responsible for inducing inflammation and pains.
BOSTON -- Preliminary findings from a prematurely halted trial suggest that osteoarthritis patients may have options beyond cyclooxygenase-2 inhibitors at their disposal for easing their pain.
Before the cyclooxygenase-2 (COX-2) inhibitors were introduced, 14 percent of Canada's population used anti-inflammatory drugs.
Mount Sinai of Medicine of New York University (New York, NY) has patented transgenic mice whose genomes comprise a gene encoding human cyclooxygenase-2 under the control of a neuron-specific promoter.
In particular, it appears to control levels of a protein called cyclooxygenase-2 (COX-2) which has a direct impact on cancer.
Cyclooxygenase-2 (Cox-2) inhibitors, such as rofecoxib (Vioxx) and celecoxib (Celebrex), are newer agents that may prove to be safer alternatives to NSAIDs in the treatment of chronic pain.
The other key study criteria, including use of endoscopic evaluation rather than symptomatology and study duration, also have been commonly used in studies of cyclooxygenase-2 (COX-2) and NSAIDs.
Objective: To investigate the expression of cyclooxygenase-2 and cluster of differentiation 95 in renal cell carcinomas having different clinico-pathological characteristics.
During inflammation, fibroblasts become activated and produce inflammatory mediators, including interleukin-8 (IL-8), monocyte chemoattractant protein-1, and express cyclooxygenase-2 (COX-2), with the resultant release of proinflammatory prostaglandins (PCs) such as [prostaglandinE.sub.2] ([PGE.sub.2]) [5, 6].
PURPOSE: Cyclooxygenase-2 (COX-2) inhibitors hold promise for cancer chemoprevention; however, recent toxicity concerns suggest that new strategies are needed.

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