Serum free light chains
showed normal [kappa] light chain
levels (1.77 g/L, reference range 1.70-3.70 g/L) and decreased [lambda] light chain
(0.71 g/L, reference range 0.90-2.10 g/L), with a normal [kappa]/[lambda] ratio of 2.49 (reference range 1.47-2.95).
TOURMALINE-AL1 (NCT01659658) is an international, randomized, controlled, open-label, multicenter, Phase 3 study, designed to determine whether NINLARO[TM] (ixazomib) in combination with dexamethasone improves hematologic response, 2-year vital organ (heart or kidney) deterioration and mortality rate versus a physician's choice of a chemotherapy regimen in participants diagnosed with relapsed or refractory systemic light chain
and Caelum Biosciences have collaborated to develop CAEL-101 for light chain
M2 PHARMA-February 1, 2019-Alexion, Caelum Biosciences Team to Develop Targeted Therapy for Light Chain
"These patients are susceptible to a frequently fatal condition called light chain
amyloidosis, in which parts of the body's own antibodies become misshapen and can accumulate in various organs, including the heart and kidneys," said study author Jan Bieschke from Washington University in St.
'The idea here is twofold, 'we wanted to understand how light chain
amyloidosis works and how the green tea compound affects this specific protein,' Bieschke added.
(10) If light chain
amyloidosis is suspected, then urine studies should also be added.
Huff-Lonergan, "Myosin light chain
1 release from myofibrillar fraction during postmortem aging is a potential indicator of proteolysis and tenderness of beef," Meat Science, vol.
With light chain
immunostaining, only k (SouthernBiotech, Birmingham, AL, USA) was identified and no A staining (SouthernBiotech) was seen (Figures 2(h) and 2(i)).
Immunoglobulin light chain
variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL).
Immunofixation of urine and serum as well as immunoglobulin-free light chain
have been traditionally used to identify the type of amyloid .
An educated and proactive lab director may know that SPEP is only 80 percent to 88 percent sensitive, and that the guidelines recommend ordering SPEP, a free light chain
test, and serum immunofixation.