One of the most commonly used PPIs is pantoprazole
. PPIs are generally considered safer and more efficacious than H2 blockers as antiulcer agents [1, 2].
It was discovered through the research that people who used the product were a third less likely to get tuberculosis than those on similar drugs, omeprazole or pantoprazole
Most PPI users were administered omeprazole (n=30; 65%); pantoprazole
was selected in eleven (24%) patients (Table 1).
In the six-year observational study, researchers found that people taking the highest recommended doses of a PPI had a 21 percent higher stroke risk, compared with similar adults who did not take PPIs Taking a high dose of pantoprazole
(Protonix) was associated with the highest risk of stroke.
But a study presented at the annual Digestive Disease Week found significant upper GI events were much more common in patients who took famotidine (Protonix), a histamine-2 receptor antagonist ([H.sub.2]RA), compared with those who took pantoprazole
(Pepcid), a PPI, as a preventive treatment.
PPIs include dexlansoprazole (Dexilant[R]), esomeprazole (Nexium[R]), lansoprazole (Prevacid[R]), omeprazole (Prilosec[R], Zegerid[R]), pantoprazole
(Protonix[R]), and rabeprazole (Aciphex[R]).
Five PPIs are licensed for use in the UK, including esomeprazole, lansoprazole, omeprazole, pantoprazole
Till April this year, even commonly available medicines like Amoxycillin and Dicloxacillin capsules ( Moxincloxa capsules) used as antibiotics, Pantoprazole
, a gastric medicine, Diclofenac sodium tablets used for inflammation and pain were found to be substandard.
(PAN, Figure 1(b)) is a type of medicine called a proton pump inhibitor (PPI).
(5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]1H-benzimidazole, PTZ, Figure 1(a)) is a selective long-acting proton pump inhibitor .
The company will initially focus on Zurcal (pantoprazole
), Riopan (Magaldrate + Dimeticone) Faktu (Policresulen, Cinchocaine hydrochloride), and Albothyl (Policresulen).
He was started with intravenous (IV) fluids and injection pantoprazole
40mg IV bid dosage.