- elotuzumab - plus pomalidomide and low-dose dexamethasone for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least two prior therapies, including lenalidomide and a proteasome
inhibitor, and have demonstrated disease progression on the last therapy.
Candidate disease-causing proteins are labelled as "expired" proteins which the proteasome
It is a thalidomide analogue indicated, in combination with dexamethasone, to treat patients with multiple myeloma who have received at least two prior therapies including lenalidomide and proteasome
In addition, an Overall Response Rate (ORR) of 86% was observed with melflufen and dexamethasone in combination with daratumumab (CD38-directed monoclonal antibody) and an Overall Response Rate (ORR) of 100% was observed with melflufen and dexamethasone in combination with bortezomib (proteasome
Youdong Mao have brought about a landmark research that provides the sharpest 3D "motion picture" of human 26S proteasome
functioning in atomic detail, and significantly advances understanding and knowledge about how the human proteasome
machinery degrades a protein substrate.
The ubiquitin proteasome
system (UPS) is the main machinery for protein degradation in all eukaryotes.
One of the mechanisms underlying immortality is the "trash disposal system" known as the proteasome
, a key node of the proteostasis network.
Herein, we identify the combination of a proteasome
inhibitor with an epigenetic modulator (histone deacetylase inhibitor (HDACi)) as a potent therapeutic strategy to overcome the deleterious effects of TP53 GOF mutations.
As other kinds of cells, RPE have a normally active UPP , and the activity of UPP decreases in different human tissues (including skin, muscle, kidney, liver, lung, heart, lentis, and RPE) with the increase of age [17, 31, 32], however, the relationship between the decline in proteasome
activity in RPE and the production of inflammatory cytokine IL-6 which plays an important role in cell growth and inflammatory reactions [30, 33] remains to be obscured.
The 20S proteasome
is a major system for the removal of oxidized protein, while the 26S proteasome
is deactivated under even mild degrees of oxidation.
The cell-permeable MG132 is a reversible, potent proteasome