reverse transcriptase


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Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitors

reverse transcriptase

n.
A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

reverse transcriptase

(trænˈskrɪpteɪz)
n
(Biochemistry) an enzyme present in retroviruses that copies RNA into DNA, thus reversing the usual flow of genetic information in which DNA is copied into RNA
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

reverse′ tran•scrip′tase

(trænˈskrɪp teɪs, -teɪz)
n.
a retrovirus enzyme that synthesizes DNA from viral RNA, the reverse of the usual DNA-to-RNA replication: used in genetic engineering.
[1970–75]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.reverse transcriptase - a polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses
polymerase - an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
He would also like to develop a new reverse transcriptase inhibitor specifically for the L1 reverse transcriptase.
The SVM technique was adequate to produce an effective QSAR model and outperformed those in the literature and the predictive stages for the inhibitory activity of reverse transcriptase by HEPT derivatives.
Results: For all patients, no significant difference was found in mRNA expressions of human telomerase reverse transcriptase and dyskerin (p>0.05), although their levels in tumour tissues were found to be higher than in normal tissues.
The researchers found telomerase reverse transcriptase gene mutations in three of the 292 smokers with emphysema, a disease in which the air sacs in the lungs are gradually damaged, making the person increasingly more short of breath.
We compared the telomere length and telomerase activity in DPaSCs with those in MSCs and found that DPaSCs possessed ideal characteristics on telomere length, telomerase activity and reverse transcriptase activity, making DPaSCs suitable alternative candidates for regenerative medicine."
Efavirenz is the non-nucleoside reverse transcriptase inhibitor of choice with rifampicin.
In particular, the recent use of the nucleos(t)ide reverse transcriptase inhibitors abacavir and didanosine has been associated with myocardial infarction in the large DAD study cohort [1].
The group conducted a study, published recently in the New England Journal of Medicine, that investigated the association of cumulative exposure to protease inhibitors and non-nucleoside reverse transcriptase inhibitors with the risk of myocardial infarction.
The survey, which looked at specimens from 3,130 newly diagnosed, drug-naive individuals, found that 4% of infections had mutations conferring resistance to nucleoside reverse transcriptase inhibitors, 7% to nonnucleoside reverse transcriptase inhibitors, and 2% to protease inhibitors.
Non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV treatment regimens are better at suppressing the virus than protease inhibitor (PI) regimens.
Identify the primary functions of each of the following viral proteins: gp120, gp41, reverse transcriptase, integrase, protease.

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