It took almost twenty years of research into his "magic bullet" thesis; but in 1910 Hoechst AG began marketing Salvarsan
as a cure, not just a treatment but a cure, for syphilis--a contagious diseases that had plagued humankind for centuries.
The introduction of this drug, arsphenamine (Salvarsan
), and its chemical derivative neoarsphenamine (Neosalvarsan) in 1910 ushered in a complete transformation of syphilis therapy and the concept of chemotherapy.
The first effective drug used to treat syphilis 6 Salvarsan
He covers malaria and anti-malarials; the painkiller aspirin; ether, chloroform, cocaine, morphine, heroine, and anesthesia; the pill; diabetes and insulin; smallpox and vaccination; vaccines to combat infectious diseases; the pox syphilis and Salvarsan
; Prontosil, Pyrimethamine, and penicillin; AIDS, HIV, and anti-retrovirals; organ transplantation and Cyclosporine; and malaria, madness, and Chlorpromazine.
Recontando las motivantes historias de las dos balas magicas de mayor impacto en medicina, creadas por Ehrlich (salvarsan
) y Rosenberg (cis-platino), los autores resaltan que el momento es oportuno y grandes esfuerzos estan en camino para disenar nuevas drogas, ya que aquellas en uso son de eficacia limitada, dificil acceso o toxicidad alta, y pronas a inducir resistencia.
After synthesizing 606 substances, he discovered arsphenamine (also known as compound 606), later named Salvarsan
, which was used for the treatment of syphilis.
Toledo-Pereyra, "History of antibiotics: from salvarsan
to cephalosporins," Journal of Investigative Surgery, vol.
 Similarly, Salvarsan
(Arsphenamide) name was given by Paul Ehrlich in 1907 that means an arsenic for salvation of human.
By that time, however, multiple, toxic treatments of arsenic compounds (salvarsan
and neosalvarsan), mercury, and other additives may have profoundly affected cell tissue and organs within the mother, unborn child, and newly-born infant (Brandt ,1985; Jones 1992).